Friday, May 1, 2020
Medical Dominance, Doctor-Patient Relationship and Deviant Behavior free essay sample
When we are sick, most of the people will go to hospital and seek help from doctors, because they have professional medical knowledge to help us cope with the diseases. Moreover, they are the important professions in the society, as everyone may get sick and they are the only one to help us relieve the pain. Therefore, this thought give rise to medical dominance over patients, other health care occupations and the whole society, resulting in an imbalance social power. Firstly, whenever we are born or died, only doctors can be the one to certificate our birth and death. As everyone needs to experience these two stages, we can only take orders from them and then this doubtless increases the medical power for doctors. Secondly, most of the specialized services need the referral from general practitioner, since they serve as the first point of contact with patients; they own the right of approval over other health professions. We will write a custom essay sample on Medical Dominance, Doctor-Patient Relationship and Deviant Behavior or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Finally, doctors are eligible to order a prescription for sick person; they have legitimated control over us and the society. All these things show that doctors are in superiority over other occupations. However, I think this phenomenon is unfair and doctors should not hold too much medical autonomy in case the overuse of power occurred. Sometimes when I watched the newspaper, there is news about the professional misconduct of doctors, for example, inappropriate sexual contact with patents, illegal or unethical prescribing, inappropriate issuing of medical certificates or keeping of medical records and so on. According to BBC news dated 5 December 2007, a top Indian doctor sought over illegal infant scans for patient, in order to let the patient knows the gender of the baby. However, medically-assisted sex selection is illegal in India to avoid abortion of girls as Indians often view a boy is superior to a girl. This reveals that doctors will also make use of their medical knowledge and power to break the law deliberately. In short, medical dominance has both advantages and disadvantages. For one thing, it benefits doctors to have autonomy to make a decision in professional practice individually, but it also entitles too much power over them to do illegal things. In my point of view, doctors should have the right to grant access to examine patientsââ¬â¢ body function and dominance in professionalism, but they need to act for the benefits of patients and the society as a whole, rather than caring for their own interest only, and thus to be a good caring professions Another topic concerned me most is doctor-patient relationship. I think a good relationship between doctor and patient is important, because it can develop trust and care with each other to increase the efficiency of consultation. Nowadays, doctors are usually in a more prominent position than patients. It seems that doctor and patient are lack of interaction and communication; it is more likely to be a question and answer section rather than assessment. It is because based of my observations, most of the doctors just simply ask the patientsââ¬â¢ questions like ââ¬Å"What symptoms do you have? â⬠, ââ¬Å"How long do you suffer from this disease? â⬠, ââ¬Å"Do you suffer from any allergies? etc.. They just keep asking these kinds of question in order to quickly examine the diseases, and then said: ââ¬Å"Next, please. â⬠I think this kind of act is a irresponsible and totally neglect the true needs of patients.
Friday, April 10, 2020
Sample of Good Narrative Essay
Sample of Good Narrative EssayA sample of good narrative essay, most often called a 'narrative monograph', is a work that is generally used in order to provide an overview on a certain subject, be it politics, psychology, sociology, literature, sports, technology, the arts or something completely different. The main purpose of this type of document is to summarize and narrate the various aspects and facets of the subject in one piece of written work. It may include both the natural and artificial aspects of the subject, which all add up to make a cohesive whole.In order to present a good narrative essay to your readers, you must have a minimum knowledge of the subject that you wish to present in the document. When you read a good narrative essay, you should know that this kind of document is written from the perspective of an author, since it is basically an analytical piece of work.While the subject matter of the good narrative essay is usually the same throughout, the styles that t he author uses to present it to the reader will vary from one work to another. There are, however, common elements that all narrative essays use in their writing, which makes it easier for the writer to sum up a subject in an organized way.A good narrative essay, as an example, will include several parts. The first part, the body, will contain descriptive sentences and explanations of the various aspects of the subject, as well as the experiences that the author had when researching the subject, which will serve as the basis for the analytical sections of the narrative essay.As you can see, the body serves as the backbone of the narrative essay. The body should give the impression that the writer has taken the time to research the subject thoroughly, and that he/she knows what he/she is talking about. It should also offer us an insight into the author's personality and passions, as well as how he/shethinks and writes.The second part of the narrative essay will focus on the strong po ints of the author, and his/her motives. These strong points should be shown in an easy to understand manner, while still being able to convince the reader that the thesis of the author is sound. In short, the strong points should be able to speak for themselves.The exposition section is essentially a period where the author will recapitulate his/her knowledge on the subject. The exposition should provide details and specific points about the subject, in an easy to understand and comprehend manner.
Saturday, March 21, 2020
Ford Essays - Dearborn, Michigan, Ford Motor Company, Henry Ford
Ford Concept car today? They can start out as simple as a dream, or a sketch on a napkin during lunch. But by the time you see them, vehicles from Ford Motor Company have been designed and tested to look and perform their best. Here are some stories that chronicle that process. Concept Cars From the Model T to the latest futuristic designs, the engineers at Ford have a long history of design innovation. Here you can get a glimpse of some of the latest visions of the cars of the future. Technology Keeping up to date with current technology is essential to ensuring reliability and safety. See how Ford puts cutting edge developments to work on important issues like Y2K compliance. Driven by Research All great innovations begin with a strong commitment to research. Meet the people behind some of our better ideas and visit places like the Ford Research Laboratory, where exciting new strides are being made in the technology that drives your car. On the Road Today Ford's commitment to the latest research and technology is evident in the cars you see on the road today. Find out more about the cars you want to drive. Best seller tomorrow Innovative solutions to keep you safe and secure. Of all the things we transport in our vehicles, the most important are our children. See what Ford is doing to help keep them safe. Learning to drive remains one of the biggest rites-of-passage for our youth. Read about some of the ways Ford is helping to train the next generation of drivers. When used correctly, they're one of the best safety devices on your vehicle. This section will answer a lot of your questions and explain how air bags work. Buckling up and making sure kids are properly restrained in the rear seat are two important ways you can help keep everyone safe. Here are some other ways Ford is helping to do the same. Dedicated to providing ingenious environmental solutions The new millennium is filled with exciting opportunities and challenges. For automotive manufacturers and their customers, there is no greater challenge than following a path that respects both the bottom line and the environment These are just a few of the ideas that ford motor company tries to keep in mind when producing their cars. Because of this they have seen overall increased sales and increases in production. They have recently purchased Volvo Ford started its production in Detroit Michigan in 1907, when Henry Ford produced the first Model T. It was a huge success and since that day Ford has been the largest car manufacture in the world Bibliography From Fords Website
Thursday, March 5, 2020
Reedsy Helped Me Start My Own Indie Publishing Company
Reedsy Helped Me Start My Own Indie Publishing Company Reedsy Helped Me Start My Own Indie Publishing Company Christina Enquist shares her experience assembling the team of professionals that helped launch her debut novel, The Immundus - and her very own independent publishing company, Odolf Mingan Publishing.I was on safari, traversing my way through the rugged terrain of social media, seeking the elusive and coveted book editor. Not just any editor would do. I knew I had to have an editor with experience in editing young adult and science fiction, preferably someone who had edited bestsellers and award-winning novels.I tried reaching out to editors on Twitter and got some bites, but I was concerned about handing my manuscript over to a person whose qualifications I wasnââ¬â¢t sure of. It was then that I happened upon a Mark Dawson podcast where he talked all about Reedsy. I began to investigate Reedsy myself and was instantly hooked. Thus ended my safari, as I found a prize better than I imagined: an entire herd of talent.I knew that I had found my resource for top talent, one that cou ld support me in starting my indie publishing career. I didnââ¬â¢t have to worry about hiring full-time or even part-time employees. I could hire professionals per project/book by contracting them through Reedsy.I am gearing up to launch my debut young adult dystopian novel,à The Immundus. The story is set in the year 2828 in Domus, the worldââ¬â¢s last remaining country. Domusââ¬â¢ population is dwindling as the result of a mysterious disease called allagine. When 16-year-old Nia is recruited by a research company pioneering a cure to allagine, she witnesses something she shouldnââ¬â¢t have. As she sets down a dangerous path that uncovers national secrets, Nia must decide not only what kind of person she wants to be, but how far sheââ¬â¢s willing to go to save humanity.In order to make The Immundus the best it could be, I connected with professionals at different stages of my bookââ¬â¢s development.EditingI contracted two editors to get my book ready for the pre sses. Katrina Diaz Arnold served as my developmental and line editor, while Parisa Zolfaghari worked as my copy editor and proofreader. Both of these women were wonderful to work with and provided exceptional feedback to help me shape my story and tighten the lines.For example, Katrina was instrumental in helping me determine where to end the book - not always a straightforward task when writing a trilogy. She also made me aware of areas where I needed more thought or dialogue so the reader could fully understand whatââ¬â¢s going on - which is crucial in any novel with dense worldbuilding. "Working with a professional editor is crucial for any novel with dense worldbuilding." @cienquist Parisa added additional depth to my story: she not only provided copy edits to make sure my punctuation and grammar were appropriate, she also provided some of her own developmental recommendations - even adding a few more scenes to raise the stakes of the novelââ¬â¢s central conflict. Since I started working with the professionals I found on Reedsy, I have learned so much about the publishing industry and its standards: from learning about widows and orphans thanks to my copy editor, to understanding bleeds and crops from my designer, my team helped me acquire the knowledge I needed to become an indie publisher.The Immundus is available for pre-order on Amazon!Please share your thoughts, experiences, or any questions for Christina Enquist in the comments below!
Tuesday, February 18, 2020
Public health Essay Example | Topics and Well Written Essays - 750 words - 1
Public health - Essay Example r gotten from over-the-counter for other reasons besides those for which they are meant or in an excess way.â⬠It is the use of any substance in a harmful pattern for the purpose of mood alteration. The drugs commonly abused include those with psychoactive effects such as alcohol, cannabis, caffeine, amphetamines, nicotine, opiates, and the hallucinogens (Boyd, 2009). Other drugs not categorized and have a potential of abuse include steroids and other drugs used for performance enhancement. In addition, some medical preparations have also been used for various intentions, besides the intended use. An example is erythropoietin, which is used to increase the volume of blood and also improve the performance of athletes. The use of the above mentioned substances has been related to abuse, physical dependence and addiction. This has led to an overall public concern on the issue of drug abuse and its health consequence. Addiction is defined as the craving of chemical substances such as drugs, tobacco and alcohol which the person addicted finds difficult to control (McCarady, 1999). National Household Survey of Drug Abuse (NHSDA) in the United States is the body concerned with epidemiological investigation of substance abuse. This survey divided the substance abuse into illicit use and abuse of drugs vs. legal use (Tobacco and alcohol). The illicit drugs are further divided in to 9 categories: cocaine, marijuana, heroin, inhalants, hallucinogens, pain relievers (non-medical use), stimulants, tranquilizers, and sedatives. The common abusers of drugs and alcohol are the adolescents due to their experimental nature and pressure from the peers. Older adolescents and young adults also make a significant contribution in the statistics. For instance, a nationwide survey taken by Monitoring the Future in 2010 on the rate of substance abuse in the US showed that 48.2% of the pupils in 12th grade had used illegal drugs in the past. 41.2% of them had taken alcohol 30days before
Monday, February 3, 2020
Netflix - SWOT analysis and managemetn characteristics PowerPoint Presentation
Netflix - SWOT analysis and managemetn characteristics - PowerPoint Presentation Example Finally, the Netflix model is future-proofed, because the streaming business that originally augmented dvd rentals can grow with the demand for streaming content. Netflix has relatively few weaknesses, but those that exist revolve around the novelty of its business model. People who are not comfortable with the internet (such as aging or rural people) will be resistant to this radical change in rental ââ¬â furthermore, the subscription service is a barrier to entry to occasional renters or those that rent movies only occasionally. There are extensive opportunities for Netflix. Its robust distribution network, able to get items to consumers in one business day, could be used to distribute other content or products should Netflix decide to expand. Video games or related media spring to mind as an especially viable option, but perhaps Netflix could also expand to book rentals, music rentals and so forth. Netflix is currently also a leader in online streaming video distribution. The obvious growth opportunity here is the development of original material for Netflix online, giving consumers a reason to stick with Netflix rather than go to the numerous copy-cats that exist and have sprung up after Netflixââ¬â¢s success. Netflix, though robust, is not immune from outside threats. One of the biggest threats is the threat to the rental industry in general: the future of media delivery is streaming, but Netflix still relies heavily on dvd rentals for its profit margins. There is danger that Netflix could hurt its own dvd business by building a more robust streaming business, and vice versa. Classic wisdom indicates that people will choose to watch content on one of those two ways, not both. Furthermore, now that Netflixââ¬â¢s model has proven profitable, they will face major competition from upstart companies that might have less pressure to make a profit and lower initial costs. Netflix has a
Sunday, January 26, 2020
Bioanalytical Technique Practical
Bioanalytical Technique Practical Introduction Improvement in technology has widened the domain of bioanalytics, reliable and reproducible data can be obtained from several instruments and protocols. The drug arena has become really competitive and it is thus imperative that an understanding of the different techniques is crucial to the isolation and analysis of biomolecules. This report is focused on the BCA assay for protein estimation and data analysis of SEC using a UPLC system. The BCA assay is a modified assay that is used for the detection and quantification of total protein in a given sample. The assay generates a purple colour which is as a result of the chelation reaction of bicinchoninic acid with cuprous ions. The complex formed as a result of the reaction is known to exhibit a very strong absorbance at a wavelength of 562nm and this shows an increasing linearity with the amount of protein in a given sample. Two main components make up the assay; the standard curve and the unknown protein sample. The BCA assay is widely used because of its sensitivity and compatibility with detergents and several other buffer types. The drawback however with the assay is that it is not as rapid as some other estimation method such as the Bradford due the incubation time required and moreover it is not an endpoint reaction as colour continues to develop even af ter incubation. The second part of this report is concerned with running a system suitability test on the waters BEH200 SEC UPLC instrument. The American and European Pharmacopeia specifically mentioned that the requirements for a system suitability testing on the day of analysis showing that it is fit for its intended use. It is worth mentioning that this has no bearing with the qualification of the instrument. Failure of any of the parameters simply means that an assay cannot commence. This testing is concerned more about the method on the day of analysis rather than the instrument per se. 1.1 Materials: Pipettes and appropriate tips Microcentrifuge tubes Microwell Plates HPLC Vials Bovine Serum Albumin Protein 2mg/ml BCA Reagent Deionised Water Perkin Elmer Plate Reader 100Mm sodium Phosphate Buffer Waters Aquity H Class Bio UPLC instrument Waters BEH200 SEC UPLC Column 1.2 Preparation of Standards: Standards were prepared as per instruction manual Table 1: Preparation of Protein Standards Calculations: Dilution factor = concentration of stock solution / concentration of diluted solution Volume of stock to add to water = Required volume of diluted solution/ Dilution factor Volume of water to add = required final volume / Volume of stock required 1.3 Preparation of Sample: The sample was prepared as per the instructions on the practical manual. Table 2: Test Sample Dilution 1.4 Preparation of BCA Reagent and Well: The BCA reagent was prepared and the 96 ââ¬âwell microplate was prepared and read in the [emailprotected] 562nm as per the instruction manual. 1.5 Data Analysis: Calculation: Equation of the linear least square fit can be represented as outlined below. Y = 0.0008 (X) ââ¬â 0.0051 0.035691= 0.0008 (X) ââ¬â 0.0051 X = 0.035691 + 0.0051/0.0008 X = 0.040791/0.0008 X = 50.98875 Taking the dilution factor into account we multiply by 5 The protein concentration is thus 50.98875 x 5 = 254.94mg/ml Discussion: The sample data had an anomaly, showing a negative reading on the third well. This is suggestive of contamination. The possibility of interference from the reagent can be ruled out because the standard was treated the same way and also taking into cognisance the fact that the experiment was not carried out under a non-denaturing condition. The likely cause could be due to dirt on the Microwell thus blocking out the necessary wavelength for the absorbance reading or the sampling pipette not delivering the right amount of reagent. The intensity of the colour change for the third well was observed to be less than the other two wells. There is also the possibility of the sample not being vortexed properly or sample settling to the bottom of tube. As mentioned earlier there seem to be an anomaly with our absorbance reading and this can be validated from our standard curve as it is not quite linear and on this basis we cannot absolutely rely on the result of the experiment. 2.1 Size Exclusion Chromatography Experiment The priming and purging of the UPLC instrument was carried out by the trainer as per the instruction manual. System suitability testing was then carried out to ensure that it is fit for purpose. The test serves to assure the reproducibility of the instrument and the method. It is a regulatory requirement which was mentioned in both the EU and US pharmacopoeias. The testing is important as it can allow for critical factors that could affect the performance of the instrument to be adjusted to meet the test criteria. Parameters such as the resolution, efficiency of the column, tailing factors, relative standard deviation etc. are used as criteria for comparison with regards to standards and test samples. The table below details the results obtained from the system suitability testing, reference standard and our test sample. The UPLC system used in our experiment can be said to be fit for purpose taking into consideration, the system suitability test. The results obtained were within our test criteria. The resolution of the peak and standard deviation of the different retention time was less than 1 which as a rule of the thumb is quite acceptable. Comparing the test sample to the reference standard one would not fail to notice that the first peak in the reference standard was a dimer while the second peak was a monomer but in our test sample the retention time of the first peak was really short showing evidence of a high molecular weight aggregation .Also from our result the second peak was our product dimer while the third peak was our product monomer. This result serves to highlight the mechanism of protein aggregation and the reason why it should be minimised as it impacts on the yield of the product and moreover it can affect the potency and therapeutic potential of the parenteral. It is also worth mentioning that sometimes early elution may not necessarily mean that there is aggregation, it could be for the simple reason that sometimes intrinsically unstructured proteins can elute so fast that they tend to behave like aggregates. A molecular weight comparison testing can be used to differentiate them. From our experiment the test sample showed increase aggregation and this can be explained given the fact that the experiment was not carried out under a non-denaturing environment. The possibility of column contamination or buffer contamination can help to encourage aggregation. It is also important that samples should be free of extraneous particles during injection as this can also be a determining factor. The changing environment of the mobile phase can also be construed as a possible cause of the aggregation observed. The temperature of the instrument is another factor that can play a role and as we all know that the Arrhenius theory of a 10à °C increase in temperature speeding up a reaction does not relate to proteins as it rather opens up the pathway of denaturation and aggregation. Questions: Estimation of protein concentration is important as we have to know the amount of protein in our final product after fermentation to know if the bioprocess has to be optimised with regards to the expected titre value. The concentration of the protein can also allow for the portioning of the product into the right dosage formulation, certain therapeutic proteins are required in a very high dosage form and their production can be sometimes targeted at a particular section of the population e.g. during an epidemic outbreak to ensure potency and biological activity. The knowledge of the concentration of proteins can also allow us to work out the economy of scale with regards to the profit margin taking into account, the expense incurred in research and development and other aspect of the production process. It is also important to estimate the amount of protein in our biomass so as to be able to optimise our subsequent purification steps. The estimation of the protein concentration can a lso give us an idea of product related impurities and those associated with the process. Proteins are very complex molecules and are prone to several types of condition than cause instability from the starting stage of production to the end of their shelf life. Aggregation can be described in a laymanââ¬â¢s term as the propensity for proteins to stick together under conditions such as a slight increase in temperature, pH, shear force, ionic strength of the solution they are contained in etc. Aggregation have been seen to cause delay in several novel biologics due to the debilitating effect on the health of the population that the drug is directed at and also in the context of compliance to regulatory authority as there is a specification to the amount of aggregates that can be allowed. It is extremely difficult if not impossible to totally eradicate aggregation from the process. It is worth mentioning however that the mechanism of aggregation is still subject to debate as it has not been fully understood. Aggregation can be reversible or irreversible depending on the stage it has attained as can be loss of primary structure. The potency of biologics as we all know are normally related to them being in their native structure, in most instances aggregation leads to the loss of activity and moreover the overall yield of the biotherapeutic is greatly affected. Aggregation has also been known to spur immune response in patients that have been administered with protein therapeutics affected by aggregation this could be by way of the neutralisation of antibodies that helps to ensure the effectiveness of the drug. In a worst case scenario the immunogenic reaction can lead to incurable conditions such as seen in patients with pure red cell aplasia where the red blood cells are attacked and blood transfusion is needed for life. The route of administration of biologics is intravenous and the presence of aggregation especially those of very high molecular size can result in the blockage of blood vessels. It is thus very important that at each stage of our production testing should be carried out to check for aggrega tion. Size exclusion chromatography is a purification system that exploits the molecular size of the compound of interest. Simply put it works just like a molecular sieve, smaller particles passes through the sieve which is the stationary phase and could be a bead coupled to a resin. The pore size of the beads are defined and on this basis it will only allow certain particle sizes to pass through while excluding those that are too large for the pore. The larger particles because they are not passing through the beads are thus excluded quickly, their retention time is thus said to be short. The smaller particles are retained longer while the larger particles earlier mentioned are eluted through the void volume. Different gels in use would typically have different pore sizes and can be used to determine the size of the molecules to be separated. Despite all the numerous advantages of size exclusion chromatography which has made it the gold standard over the years for analysing protein aggregation there are still some limitation associated this method. The possibility of the stationary phase and the analyte reacting together can be sometimes rife thus leading to a longer retention time which serves to mimic the compound as being of low molecular size. The cost associated with running this type of separation technique can also be enormous due to the fact that large columns and eluents are required and this serves to add to the overall cost of the unit operation. In comparison to other modes of separation, size exclusion chromatography can be said to have an inherent low resolution as there is a limited range of molecular weight that can be separated as a result of dependence on the pore size of the beads in use. There is also the possibility of proteolytic degradation as the protein of interest can become targets for proteolyt ic enzymes still present in solution. The accuracy of this technique can sometimes come into question due to the fact some aggregates will remain in solution and as such would not be detected. Also taking into consideration the fact that larger molecular aggregate leaves the column through the void volume, there is also the possibility. The possibility of the polymer in use to degrade is also a drawback as this can occur at a very high flow rate. The high flow rate as mentioned earlier can degrade the polymer and it also has the ability of altering the geometry of the beads in use making the separation technique inefficient
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